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Ulf Landegren Xingqi Chen — Studies of the cell fate decision using single-cell technologies The focus of our work is to understand cell single i lövstalöt decision during development and human disease.
We are developing state-of-art single cell technologies to characterize cell heterogeneity in a systematic manner, and to identify key players involved in controlling specific cell fates.
In our group we are fascinated by why cells in our body contain the exactly same DNA sequence but single i lövstalöt into different fates. For instance, what is it that makes some cells in the human bodies become cancer and not others?
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And how can stem cells differentiate into totally different cell types? Our main aim is to understand the role of epigenetics in controlling cell fate in human disease and we have adopted two main approaches to accomplish this: Deciphering the tumour microenvironment across multiple primary clinical cancer types with single cell technologies.
Developing the start-of-art single cell technologies. The insight from our research could give us better knowledge of cancer progression at the single cell level, and provide a potential clinical diagnosis toolkit. A long-term goal is to reveal a target for cancer therapy.
Characterising multi-layers of information in single cells The recent advance in single cell technologies e. To completely understand cell heterogeneity, we need to characterize multi-layers of information, including nucleus architecture, epigenetics, transcriptome and protein expression, as a circuitry loop from the exactly same cell.
Both technologies are single cell technologies and can be used to analyse multi-layers of cell features at the same time either in vitro or ål single situ. These will now be employed in my planned projects.
More information on the group web site: www. Please contact xingqi.
Xingqi Chen's group.